ABRx™ Antibiotic Resistance Panel

The Diatherix Eurofins ABRx™ Antibiotic Resistance Panel provides detection for seventeen gene types and seven gene classes associated with resistance to three major groups of antibiotics: ╬▓-lactams (penicillins, cephalosporins, carbapenems), fluoroquinolones, and macrolides. The ABRx Panel is built on a nanofluidic real-time PCR OpenArray┬« platform which allows spatial assay multiplexing and detection of resistance genes directly from a clinical specimen.

Benefits:

  • Delivers one-day results
  • Direct detection in clinical samples; bacterial isolation not required
  • Validated on respiratory secretions, rectal/stool swabs, and urine samples
  • Clinical isolates can be used for testing
  • Inclusive for detection of multiple gene variants: clinically relevant and prevalent gene variants within an individual gene type will be detected
  • Detection results can be used to define an antibiotic class avoidance strategy

ABRx™ Antibiotic Resistance Panel:

    CTX-M Group 1
    CTX-M Group 2
    CTX-M Group 8/25
    CTX-M Group 9
    KPC
    IMP
    VIM
    NDM
    FOX

    OXA-1
    OXA-48
    PER
    VEB
    GES
    ermB
    qnrA
    qnrS

Report Format:

Antibiotic Class Panel Target Antibiotic Class Avoidance
β-Lactam CTX-M Group 1 cephalosporins, penicillins, aztreonam
CTX-M Group 2 cephalosporins, penicillins, aztreonam
CTX-M Group 8/25 cephalosporins, penicillins, aztreonam
CTX-M Group 9 cephalosporins, penicillins, aztreonam
KPC carbapenems, cephalosporins, penicillins, β-lactamase inhibitors, aztreonam
IMP carbapenems, cephalosporins, penicillins, β-lactamase inhibitors
VIM carbapenems, cephalosporins, penicillins, β-lactamase inhibitors
NDM carbapenems, cephalosporins, penicillins, β-lactamase inhibitors
FOX cephalosporins, penicillins, β-lactamase inhibitors
OXA-1 cloxacillin, oxacillin, penicillins
OXA-48 carbapenems, extended spectrum cephalosporins, penicillins, β-lactamase inhibitors
PER extended spectrum cephalosporins, penicillins, aztreonam
VEB extended spectrum cephalosporins, penicillins, aztreonam
GES carbapenems, cephamycins, extended spectrum cephalosporins, penicillins
Macrolide ermB macrolides (erythromycin, clindamycin, azithromycin)
Fluoroquinolone qnrA fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin)
qnrS fluoroquinolones (ciprofloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin)